Analysis of seizure risk factors after allogeneic hematopoietic stem cell transplantation: a 8 case report and literature review.
10.1007/s11596-013-1176-x
- Author:
Zhao-Dong ZHONG
1
;
Lei LI
1
;
Yao-Hui WU
2
;
Yong YOU
1
;
Wei-Ming LI
1
;
Ping ZOU
1
Author Information
1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
2. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. wyh11035@sina.com.
- Publication Type:Case Reports
- MeSH:
Adolescent;
Adult;
Anticonvulsants;
therapeutic use;
Fatal Outcome;
Female;
Follow-Up Studies;
Hematopoietic Stem Cell Transplantation;
adverse effects;
methods;
Humans;
Male;
Phenytoin;
therapeutic use;
Retrospective Studies;
Seizures;
diagnosis;
drug therapy;
etiology;
Transplantation, Homologous;
Treatment Outcome;
Valproic Acid;
therapeutic use;
Young Adult
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2013;33(5):656-660
- CountryChina
- Language:English
-
Abstract:
The clinical characteristics of patients with seizures after allogeneic hematopoietic stem cell transplantation (allo-HSCT) were analyzed. A total of 8 cases of seizures after allo-HSCT were investigated. Clinical data of these cases were studied retrospectively. Of 159 cases subjected to allo-HSCT, seizure occurred in 8 cases during 29-760 days after transplantation, median survival time was 46 days, and there were 6 cases of tonic-clonic seizure. The incidence of seizure after matched unrelated HSCT was higher than that after related HSCT (P=0.017). Of 7 cases treated with cyclosporine A (CsA), 4 cases obtained high blood levels of CsA. In addition, hyponatremia was diagnosed in 5 cases. Abnormal electroencephalogram and brain MRI findings were found in some cases. During 20 days after seizure, 2 cases died due to infection and graft-versus-host disease (GVHD), respectively. It was suggested that multiple factors are associated with seizures after allo-HSCT. Rapid identification and correction of the causative factors are very important to prevent permanent central nervous system damage and reduce the mortality.
