Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets.
- Author:
Tongyan WANG
1
;
Qihua CUI
;
Qingri CAO
;
Jinghao CUI
Author Information
- Publication Type:Journal Article
- MeSH: Acetophenones; pharmacokinetics; therapeutic use; Animals; Colitis, Ulcerative; drug therapy; Colon; drug effects; Drug Delivery Systems; methods; Excipients; chemistry; Humans; Hydrogen-Ion Concentration; Rats; Rats, Sprague-Dawley; Tablets, Enteric-Coated; chemistry; beta-Cyclodextrins; chemistry
- From: China Journal of Chinese Materia Medica 2011;36(21):2956-2959
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.
METHODThe core tablets were prepared with the mixture of Pae-beta-CYD inclusion complex, peotin and calcium acetate, and coated with ethanolic solution of Eudragit S100. The effects of coating weight, amount of plasticizer, curing time and temperature on the release of drug from tablets were investigated in vitro.
RESULTAbout 5-6 h retarded release of paeonol in the dissolution media of pectinase or rats colon contents were obtained by 12% coating weight gain and 20% Dibutyl phthalate (DBP) was used as plasticizer, and subsequently curing the tablets at 45 degrees C for 12 h.
CONCLUSIONPae-beta-CYD loaded colon-specific release tablets showed pH environment and enzyme dependant release properties.
