Percutaneous permeability study for patches Shangshi Zhitong on different kinds of bases.
- Author:
Xiaoping YAN
1
;
Shijie GUAN
;
Rui ZHENG
;
Bowen YI
;
Yonggang WANG
;
Yonghong ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drugs, Chinese Herbal; analysis; pharmacokinetics; Male; Permeability; Rats; Rats, Sprague-Dawley; Skin; drug effects; metabolism
- From: China Journal of Chinese Materia Medica 2011;36(21):2960-2962
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine.
METHODUsing modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC.
RESULTThe average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%, 74.52% were 34.32%, respectively, and on old base are 54.90%, 50.24%, 46. 54%, respectively.
CONCLUSIONThe new base benefits the lipophilic drugs and releases more stably.
