OBJECTIVETo investigate USMM coupled techniques applied in active ingredient extraction and separation of Salvia.

METHODSupercritical fluid extraction (SFE) CO2 was used to extract and separate tanshinone liposoluble constituent, ultrasonic was used to extract danshen phenolic acids ternate, membrane separation and macroporous resin was used to purify water extraction from HDP. Transfer rate and purity of Danshen active ingredients were employed as the investigation indexes, the feasibility of USMM technology used in extraction and separation S. miltiorrhiza was investigated.

RESULTSFE-CO2 extraction process for S. miltiorrhiza was stable and feasible. Danshen phenolic acids extracted from slag of SFE-CO2 by ultrasound got a high yield. Macroporous resin purification technology could improve the purity of active ingredients of S. miltiorrhiza. Membrane separation and membrane separation coupled with macroporous resin technology applied to the purification process of S. miltiorrhiza phenolic acids still needed further research.

CONCLUSIONIt is feasible basically that USMM technology apply in extraction and separation of Salvia active ingredient.