Effect of compatibilities and proportions of shuanglong formula on acute myocardial infarction in rats.
- Author:
Xiaoping LIANG
1
;
Xi CHEN
;
Yiming WANG
;
Qionglin LIANG
;
Jun WU
;
Guoan LUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Electrocardiography; drug effects; Isoproterenol; Male; Myocardial Infarction; drug therapy; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2011;36(22):3176-3179
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo verify the rational of Chinese medicine Shuanglong formula.
METHODRat models of acute myocardial ischemia were induced by hydrochloride isoproterenol. ECG J point change, myocardial infarction area and cellular enzyme (CK, LDH, SOD and MDA) levels were observed and detected to show protective effect of treatment groups.
RESULTThe single drug prescriptions and compatibilities both could improve ECG performance, decrease levels of CK, LDH, SOD and MDA in serum, and reduce a certain myocardial infarct size.
CONCLUSIONThe Shuanglong formula at the high dose of 3:7 was proved to be more effective on myocardial ischemia.
