Studies on antidiabetic effects of cortex Moutan polysaccharide-2b in type 2 diabetes mellitus rats.
- Author:
Hao HONG
1
;
Qin-mao WANG
;
Zhi-ping ZHAO
;
Guo-qing LIU
;
Ye-shou SHEN
;
Guang-liang CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Body Weight; drug effects; Diabetes Mellitus, Experimental; drug therapy; Drugs, Chinese Herbal; chemistry; Glucose Intolerance; Hypoglycemic Agents; isolation & purification; therapeutic use; Insulin; blood; Liver; metabolism; Male; Paeonia; chemistry; Plant Roots; chemistry; Plants, Medicinal; chemistry; Polysaccharides; isolation & purification; therapeutic use; Rats; Rats, Wistar; Receptor, Insulin; metabolism
- From: Acta Pharmaceutica Sinica 2003;38(4):255-259
- CountryChina
- Language:English
-
Abstract:
AIMTo study the antidiabetic effects of cortex Moutan polysaccharide-2b (CMP-2b) in type 2 diabetes mellitus (T2DM) rats.
METHODSThe T2DM model rats were induced by a single intravenous injection of low dose streptozotocin (STZ) and intake of high sucrose-fat diet. CMP-2b was given to T2DM rats daily through gavage for 4-5 weeks. The body weight, water and food intake, fasting blood glucose (FBG), glucose tolerance, plasma lipids, serum insulin, and insulin receptor (Ins R) were determined.
RESULTSOral administration of CMP-2b significantly decreased water and food intake, FBG, total cholesterol (Tch), and triglyceride (TG), improved the impaired glucose tolerance (IGT), and remarkably raised the number of low affinity InsR and insulin sensitivity index (ISI) in T2DM rats.
CONCLUSIONCMP-2b may be useful for treating T2DM and its complications.
