Synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.
- Author:
Fa-qing YE
1
;
Li CHEN
;
Jin-min HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Infective Agents; chemical synthesis; chemistry; pharmacology; Ciprofloxacin; antagonists & inhibitors; chemical synthesis; pharmacology; Combinatorial Chemistry Techniques; methods; Enoxacin; antagonists & inhibitors; chemical synthesis; pharmacology; Escherichia coli; drug effects; Female; Mice; Microbial Sensitivity Tests; Molecular Structure; Nitroimidazoles; chemistry; Norfloxacin; antagonists & inhibitors; chemical synthesis; pharmacology
- From: Acta Pharmaceutica Sinica 2003;38(4):260-263
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the synthesis and antibacterial activity of pyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol.
METHODSPyridonecarboxylic acid derivatives containing 2-methyl-5-nitroimidazol were synthesized primarily from 2-methyl-5-nitroimidazol, norfloxacin, ciprofloxacin, enoxacin via nucleophilic substitution and esterification. The antibacterial activity of the nine target compounds were tested.
RESULTSNine new compounds were synthesized (IIa-c and IIIa-f). The structure of the title compounds were identified by 1HNMR, MS as well as elementary analysis.
CONCLUSIONCompounds IIa, IIb and IIc showed antibacterial activity, and were worth further studying.
