Studies on the chemical constituents of the aerial part of Cimicifuga foetida L.
- Author:
Rui-le PAN
1
;
Di-hua CHEN
;
Jian-yong SI
;
Xiao-hong ZHAO
;
Lian-gang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Cimicifuga; chemistry; Drugs, Chinese Herbal; chemistry; isolation & purification; Molecular Structure; Plant Components, Aerial; chemistry; Plants, Medicinal; chemistry; Sitosterols; chemistry; isolation & purification
- From: Acta Pharmaceutica Sinica 2003;38(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo look for new active constituents from the aerial part of Cimicifuga foetida L.
METHODSVarious column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences.
RESULTSFive 9,19-cycloartane triterpenoid saponins and one sitosterol saponin were obtained and identified as cimifoetiside I [12 beta-hydroxycimigenol-3-O-beta-D-galactoyranoside, (1)], cimifoetiside II [(23R,24R) cimigenol-3-O-beta-D-galactopyranoside, (2)], cimigenol-3-O-beta-D-galactopyranoside (3), 12 beta-hydroxycimigenol-3-O-beta-D-xylopyranoside (4), 12 beta-hydroxycimigenol-3-O-alpha-L-arabinopyranoside (5), daucosterol (6).
CONCLUSIONCompounds 1 and 2 are new and compounds 4 and 5 were isolated from this plant for the first time.
