Alkaloids from a Tibetan medicine Meconopsis quintuplinervia Regel.
- Author:
Xiao-ya SHANG
1
;
Jian-gong SHI
;
Yong-chun YANG
;
Xing LIU
;
Chong LI
;
Cheng-zhong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; isolation & purification; Medicine, Tibetan Traditional; Molecular Conformation; Molecular Structure; Morphinans; chemistry; isolation & purification; Morphine Derivatives; chemistry; isolation & purification; Papaveraceae; chemistry; Plants, Medicinal; chemistry
- From: Acta Pharmaceutica Sinica 2003;38(4):276-278
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo reinvestigate the chemical constituents of the ethanolic extract of Meconopsis quintuplinervia Regel which is a traditional Tibetan medicine used for treatments of hepatitis, tuberculosis etc..
METHODSThe compounds were enriched by column chromatography techniques over silica gel, macro porous resin and Sephadex LH-20 absorbents, and finally purified by reverse phase preparative HPLC methods with isocratic mobile phase systems of methanol-H2O-acetic acid (500:500:1) and acetonitrile-H2O-acetic acid (200:800:1). Structural determination of the pure compounds were based on extensive analyses of modern spectroscopic methods including IR, MS, HRMS, 1D- and 2D-NMR spectra.
RESULTSThree alkaloids were obtained and their structures were elucidated as norsanguinarine (I), O-methylflavinantine (II) and 6-methoxy-17-methyl-2, 3-[methylenebis (oxy)]-morphin-5-en-7-one (III).
CONCLUSIONNorsanguinarine (I) was isolated from genus Meconopsis for the first time, and 6-methoxy-17-methyl-2,3-[methylenebis(oxy)]-morphin-5-en-7-one (III) is a new alkaloid named as meconoquintupline.
