Study on Aconitum diterpenoid alkaloids from flowers of Aconitum kusnezoffi and its decoction by ESI-MS.

Yong WANG; Zhi-qiang LIU; Feng-rui SONG; Shu-ying LIU

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Study on Aconitum diterpenoid alkaloids from flowers of Aconitum kusnezoffi and its decoction by ESI-MS.

Author: Yong WANG ¹ ; Zhi-qiang LIU ; Feng-rui SONG ; Shu-ying LIU
Author Information

1. New Drug Lab of Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Department of Chemistry, Northeast Normal University, Changchun, China.
Publication Type:Journal Article
MeSH: Aconitum; chemistry; Alkaloids; analysis; chemistry; isolation & purification; Drugs, Chinese Herbal; chemistry; isolation & purification; Flowers; chemistry; Hot Temperature; Hydrolysis; Molecular Structure; Plants, Medicinal; chemistry; Spectrometry, Mass, Electrospray Ionization
From: Acta Pharmaceutica Sinica 2003;38(4):290-293
CountryChina
Language:Chinese
Abstract:
AIMTo study the change of chemical compound after decocting the flowers of Aconitum kusnzoffii Reichb (FAK) by analyzing the alkaloids in FAK and the decoction of FAK qualitatively.
METHODSThe alkaloid extracts of FAK and alkaloid mixtures in the decoction of FAK were directly analyzed by electrospray ionization trap tandem mass spectrometry via by pump.
RESULTSThree novel aconitum alkaloids were found in FAK. In addition, it is found that both diester diterpenoid alkaloids and triester diterpenoid alkaloids were hydrolyzed in the decoction of FAK. The hydrolysis products of the diester-alkaloids are benzoylaconines and aconines; the hydrolysis products of the triester-alkaloids are 3-acetyl-aconines.
CONCLUSIONESI-MS" method is suitable for the analysis of Aconitum alkaloids in the decoction of FAK as well as other Aconitum plants, which offers the advantages of convenience, speed, sensitivity and specificity.