Studies on structure modification of (+)-praeruptorin A.
- Author:
Xian-li WU
1
;
Ling-yi KONG
;
Zhi-da MIN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aorta, Thoracic; drug effects; Apiaceae; chemistry; Calcium Channel Blockers; chemical synthesis; isolation & purification; pharmacology; Coumarins; chemical synthesis; isolation & purification; pharmacology; Drugs, Chinese Herbal; chemical synthesis; isolation & purification; pharmacology; Molecular Structure; Muscle Contraction; drug effects; Muscle, Smooth, Vascular; drug effects; Plants, Medicinal; chemistry; Rats
- From: Acta Pharmaceutica Sinica 2002;37(7):527-534
- CountryChina
- Language:Chinese
-
Abstract:
AIMIn order to look for new active compounds, the structure of (+)-praeruptorin A is modified.
METHODS(+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out.
RESULTSEighteen compounds were semi-synthesized from (+)-praeruptorin A.
CONCLUSIONFourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.
