Identification of four new ceramides from Anthopleura pacifica.
- Author:
Shu-yu ZHANG
1
;
Hai-feng TANG
;
Yang-hua YI
;
Ling LI
;
Da-zheng ZHOU
;
Zheng-rong ZOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biological Assay; Ceramides; chemistry; isolation & purification; Cnidarian Venoms; chemistry; Mitosporic Fungi; drug effects; Molecular Conformation; Molecular Structure; Sea Anemones; chemistry
- From: Acta Pharmaceutica Sinica 2003;38(5):350-353
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the bioactive constituents from Anthopleura pacifica.
METHODSCompounds were separated by Pyricularia oryzae bioassay-guided fractionation method with a combination of multi-chromatography. Their chemical structures were determined on the basis of spectral analysis and chemical evidence.
RESULTSA portion showing activity against P. oryzae was obtained and from the portion four compounds were identified as N-hydroxyethyl-N-tetradecanoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine (a), N-hydroxyethyl-N-(9Z-hexadecenoyl)-(2S,3R)-octadecasphinga-4 (E), 8 (E)-dienine (b), N-hydroxyethyl-N-hexadecanoyl-(2S,3R)-octadecasphinga-4(E), 8 (E)-dienine (c) and N-hydroxyethyl-N-(13Z-docosenoyl-(2S,3R)-octadecasphinga-4(E), 8(E)-dienine(d).
CONCLUSIONAll the four compounds are new ceramides.
