Study on the pharmacokinetics of scutellarin in dogs.
- Author:
Xue-hua JIANG
1
;
Su-hua LI
;
Ke LAN
;
Jun-yi YANG
;
Jing ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apigenin; Area Under Curve; Asteraceae; chemistry; Chromatography, High Pressure Liquid; Dogs; Drugs, Chinese Herbal; administration & dosage; isolation & purification; pharmacokinetics; Female; Flavonoids; blood; isolation & purification; pharmacokinetics; Glucuronates; blood; isolation & purification; pharmacokinetics; Injections, Intravenous; Male; Plants, Medicinal; chemistry; Vasodilator Agents; administration & dosage; pharmacokinetics
- From: Acta Pharmaceutica Sinica 2003;38(5):371-373
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo determine scutellarin in dog plasma and study the pharmacokinetics of scutellarin in the dog.
METHODSScutellarin in plasma of six dogs at different sampling time was determined after single dose of 120 mg i.v. by RP-HPLC. The mean plasma concentration-time curve was protracted and pharmacokinetic parameters were calculated.
RESULTSThe concentration-time curve of scutellarin can be fitted to a three-compartment model with the main pharmacokinetic parameters as follows: T1/2 gamma, T1/2 alpha and T1/2 beta were (1.1 +/- 0.8) min, (7.0 +/- 2.8) min and (52 +/- 29) min, respectively, Vc was (880 +/- 508) mL, CL was (190 +/- 54) mL.min-1, AUC0-90 and AUC0-infinity were (574 +/- 134) mg.min.L-1 and (559 +/- 132) mg.min.L-1 respectively.
CONCLUSIONThe concentration of scutellarin in plasma declined rapidly after single dose of 120 mg i.v. in dogs, and this suggested that the T1/2 of scutellarin should be taken into account in preparation exploitation and drug administration.
