Study on the active spirostanol saponins of Gualou xiebai baijiutang.
- Author:
Xiang-jiu HE
1
;
Nai-li WANG
;
Feng QIU
;
Xin-sheng YAO
Author Information
- Publication Type:Journal Article
- MeSH: Allium; chemistry; Animals; Drug Combinations; Drugs, Chinese Herbal; chemistry; isolation & purification; pharmacology; Ethanol; Fruit; chemistry; Molecular Structure; Plants, Medicinal; chemistry; Platelet Aggregation; drug effects; Rabbits; Saponins; chemistry; isolation & purification; pharmacology; Trichosanthes; chemistry
- From: Acta Pharmaceutica Sinica 2003;38(6):433-437
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the basis of actions of Gualou xiebai baijiutang.
METHODSGuided by bioactivities, chemical and chromatographic ways were applied to isolate and purify the prescription. The chemical structures were identified by chemical and spectral ways. The activities on cardiovascular system of the pure compounds were measured.
RESULTSSeven steroidal compounds were isolated and identified from the active parts.
CONCLUSIONCompounds 5 and 6 showed good anti-platelet aggregation activities induced by ADP and PAF. The IC50 of compound 5 and 6 induced by 2 mumol.L-1 ADP were 0.082 and 0.078 mmol.L-1, and the IC50 induced by 0.5 mumol.L-1 PAF were 0.182 and 0.151 mmol.L-1, respectively.
