Preparation and antibacterial activity of quaternary ammonium salt monomers
10.3321/j.issn:1002-0098.2008.06.013
- VernacularTitle:牙科季铵盐类单体的制备及其抗菌作用的研究
- Author:
Yu-Hong XIAO
1
;
Ji-Hua CHEN
;
Ming FANG
;
Xiao-Dong XING
;
Fang LI
;
Zhi-Guo CHAI
Author Information
1. 第四军医大学口腔医学院
- Keywords:
Microbial sensitivity tests;
Dental materials;
Quaternary ammonium salt;
Monomer
- From:
Chinese Journal of Stomatology
2008;43(6):370-373
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare three quaternary ammonium salt (QAS) monomers, and to compare their antibacterial activities against four oral bacterial strains. Methods Three antibacterial monomers [ methacryloxylethyl benzyl dimethyl ammonium chloride(DMAE-BC) , methacryloxylethyl m-chloro benzyl dimethyl ammonium chloride( DMAE-m-CBC ), methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB) ] were synthesized according to the general structure of target monomers. Their antibacterial effects were investigated using the broth dilution test on Gram-positive and Gram-negative bacterial strains ( Streptococcus mutans ,Streptococcus sanguis, Porphyromonas gingivalis, Prevotella melaninogenica). Results Three different monomers were successfully obtained. All the tested bacterial strains were susceptible to the three monomers, among which DMAE-CB exhibited the lowest minimal inhibitory concentrations (MIC) ranging from 1.2 to 4. 8 mg/L Conclusions All these three QAS monomers have different antibacterial activities against four oral bacteria strains. The data indicate that DMAE-CB may be a candidate antibacterial agent for oral infectious diseases.
