OBJECTIVETo detect the susceptible alleles in generalized aggressive periodontitis patients and healthy controls and to analyze the effect of multi-alleles on the occurrence and development of generalized aggressive periodontitis.

METHODSPolymerase chain reaction and cleavage were used for detecting the frequencies of five susceptible genetic polymorphisms in generalized aggressive periodontitis patients and healthy controls. The results were analyzed by Z-score test and mean square analysis.

RESULTSThe frequencies of homozygous for HLA-DRB1* 1501 allele, TNF-A-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X in generalized aggressive periodontitis patients were higher than those in healthy controls. The persons who took more than three susceptible alleles (including three susceptible alleles) had more severe periodontal conditions than the ones who took less than three susceptible alleles (not including three susceptible alleles).

CONCLUSIONSHLA-DRB1 * 1501 allele, TNFA-308 allele II, IL-1B(+3953) allele II, vitamin D receptor allele A, T, estrogen receptor allele X are susceptible alleles in generalized aggressive periodontitis. Carrying more than three susceptible alleles has a great effect on the occurrence and development of generalized aggressive periodontitis.