Screening and analysis of multi-alleles in generalized aggressive periodontitis
10.3321/j.issn:1002-0098.2008.07.008
- VernacularTitle:广泛型侵袭性牙周炎多种等位基因的筛查与分析
- Author:
Hong-Yan WANG
1
;
Ya-Ping PAN
Author Information
1. 中国医科大学口腔医学院
- Keywords:
Periodontitis;
Alleles;
Gene frequency;
Polymerase chain reaction
- From:
Chinese Journal of Stomatology
2008;43(7):406-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the susceptible alleles in generalized aggressive periedontitis patients and healthy controls and to analyze the effect of multi-alleles on the occurrence and development of generalized aggressive periodontitis. Methods Polymerase chain reaction and cleavage were used for detecting the frequencies of five susceptible genetic polymorphisms in generalized aggressive periodontitis patients and healthy controls. The results were analyzed by Z-score test and mean square analysis. Results The frequencies of homozygous for HLA-DRB1* 1501 allele, TNF-A-308 allele Ⅱ, IL-1B+3953 allele Ⅱ , vitamin D receptor allele A, T, estrogen receptor allele X in generalized aggressive periodontitis patients were higher than those in healthy controls. The persons who took more than three susceptible alleles (including three susceptible alleles) had more severe periodontal conditions than the ones who took less than three susceptible alleles(not including three susceptible alleles). Conclusions HLA-DRB1* 1501 allele, TNF-A-308 allele Ⅱ, IL-1B+3953allele Ⅱ, vitamin D receptor allele A, T, estrogen receptor allele X are susceptible alleles in generalized aggressive periodontitis . Carrying more than three susceptible alleles has a great effect on the occurrence and development of generalized aggressive periodontitis.
