Relationship between interleukin-6 gene-572C/G polymorphism and chronic periodontitis.
- Author:
Ze-min GUAN
1
;
Jing-jin LIU
;
Xin MA
;
Dong-hong WU
;
Jie YU
;
Guo-qiang HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Case-Control Studies; Chronic Periodontitis; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-6; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide
- From:Chinese Journal of Stomatology 2008;43(7):410-413
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between interleukin-6 (IL-6) gene -572C/G polymorphism and the risk of chronic periodontitis disease.
METHODSIL-6-572C/G genotype polymorphism was examined in 93 patients with chronic periodontitis and 96 control subjects by PCR restriction fragment length polymorphism (PCR-RFLP) method.
RESULTSIL-6-572GG genotype and G allele were more frequent in chronic periodontitis patients than that in control subjects (P<0.05). -572CC, CG and GG genotype frequency were 52.7 % , 40.9 %, 6.4 % in chronic periodontitis patients and 67.7 %, 31.3%, 1.0 % in control subjects, respectively. -572CG + GG genotype and G allele were more frequent in patients than that in control subjects (P<0.05). Compared with CC genotype,the odds ratio for chronic periodontitis was 1.88 (95% CI: 1.04-3.40, P<0.05) for CG + GG genotype.
CONCLUSIONSThe frequency of -572CG + GG genotype was higher in patients with chronic periodontitis compared with the control subjects. IL-6-572C/G polymorphism may be a genetic susceptibility factor for chronic periodontitis in Chinese Hans population.