Prophylactic administration of Yunnan Baiyao capsule reduces intra-operative blood loss in orthognathic surgery
10.3321/j.issn:1002-0098.2008.09.009
- VernacularTitle:口服云南白药对正颌外科术中出血量影响的随机双盲对照研究
- Author:
Zheng-Long TANG
1
;
Xing WANG
;
Biao YI
;
Zi-Li LI
;
Chang HANG
;
Xiao-Xia WANG
Author Information
1. 贵阳医学院附属医院
- Keywords:
Yunnan Bai Yao;
Blood less,surgical;
Orthognathie surgery
- From:
Chinese Journal of Stomatology
2008;43(9):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the haemostatie ~cacy and safety of prophylactic oral administration of Yanan Baiyao capsules on reduction of blood loss in bimaxillary orthognathic surgery.Methods Eighty-seven patients scheduled for Le Fort I esteotomy and bilateral sagittal split ramus osteotomy(BSSRO) were enrolled in the prospective, randomized, double-blind, placebo-controlled clinical study. Forty-three patients took prophylactic oral administration of Yurman Baiyao capsules 3 days before operation, and 44 patients without Yunnan Baiyao administration served as controL The intranperative blood loss during Le Fort I osteotomy and bilateral sagittal split ramus osteotomy was estimated and the safety of Yunnan Baiyao capsules was evaluated. Results The total blood loss in the Yunnan Baiyao group (330.5±134.4) ml was significantly lower than that of the control group (420. 3±175.9) ml. The blood loss of Le Fort I osteoromy in the Yunnan Baiyao group (154.9±84.3) ml was also significantly lower than that of the control group (203.8±98.1) ml. The mean blood loss of BSSRO in the Yunnan Baiyao group was also lower than that of the control group, but the differences was not significant. The post-operative fibrinolysis was in the same level in both groups. Thromboemblic events or other side effects were not observed in this clinical trial Condusions Prophylactic oral administration of Yunnan Baiyao capsules can effectively reduce the intra-operative blood loss in bimaxillary orthoguathic surgery. Yunnan Baiyao capsule are an effective and safe haemostatie traditional Chinese medicine.
