Effect of Coenzyme Q10 on Radiation Nephropathy in Rats.
10.3346/jkms.2017.32.5.757
- Author:
Yongkan KI
1
;
Wontaek KIM
;
Yong Ho KIM
;
Donghyun KIM
;
Jin Sook BAE
;
Dahl PARK
;
Hosang JEON
;
Ju Hye LEE
;
Jayoung LEE
;
Jiho NAM
Author Information
1. Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea. rokwt@hanmail.net
- Publication Type:Original Article
- Keywords:
Coenzyme Q10;
Radiation Therapy;
Total Body Irradiation;
Radiation Nephropathy;
Rats
- MeSH:
Abdominal Cavity;
Animals;
Blood Urea Nitrogen;
Creatinine;
Fibrosis;
Humans;
Kidney;
Rats*;
Soybean Oil;
Whole-Body Irradiation
- From:Journal of Korean Medical Science
2017;32(5):757-763
- CountryRepublic of Korea
- Language:English
-
Abstract:
The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P < 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P < 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.
