Effect of Combined Treatment with Cyclosporine A and Cord Serum for Dry Eye Associated with Graft-Versus-Host-Disease.
10.3341/jkos.2013.54.4.587
- Author:
Jung Han CHOI
1
;
Han Jin OH
;
Kyung Chul YOON
Author Information
1. Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclosporin A;
Dry eye;
Graft-versus-host disease;
Umbilical cord serum
- MeSH:
Cyclosporine;
Eye;
Graft vs Host Disease;
Humans;
Ophthalmic Solutions;
Tears;
Umbilical Cord
- From:Journal of the Korean Ophthalmological Society
2013;54(4):587-594
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the efficacy of combined treatment with 0.05% cyclosporine A and 20% umbilical cord serum eye drops for severe dry eye associated with graft-versus-host disease (GVHD). METHODS: Eighteen patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A and 20% umbilical cord serum eye drops (group 1, n = 16), 0.05% cyclosporine A eye drops (group 2, n = 10) or artificial tears only (group 3, n = 10). Tear film break up time (BUT), Schirmer test, tear clearance rate (TCR), and keratoepithelio pathy score were measured before and 1, 3 and 6 months after treatment. RESULTS: In group 1, significant improvement was observed in tear film BUT (from 3.25 +/- 1.18 s to 6.63 +/- 0.96 s, p < 0.01), TCR (from 2.38 +/- 0.72 to 3.13 +/- 0.72, p < 0.01) and keratoepithelio pathy score (from 6.31 +/- 2.15 to 0.88 +/- 0.89, p < 0.01) 6 months after treatment. Compared with group 2 and group 3, group 1 showed significant improvement in BUT (3 and 6 months after treatment) and keratoepitheliopathy score (1, 3 and 6 months after treatment). CONCLUSIONS: Combined treatment with 0.05% cyclosporine A and 20% umbilical cord serum eye drops is effective for severe dry eye associated with GVHD.
