The role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and the inhibitors.
- Author:
Yan JIANG
1
;
Xin-yong LIU
Author Information
1. Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
- Publication Type:Journal Article
- MeSH:
Amphotericin B;
analogs & derivatives;
chemistry;
pharmacology;
Anti-HIV Agents;
chemistry;
pharmacology;
Benzeneacetamides;
chemistry;
pharmacology;
Furans;
chemistry;
pharmacology;
Genes, gag;
HIV-1;
drug effects;
physiology;
Humans;
Phenylurea Compounds;
chemistry;
pharmacology;
Piperidines;
chemistry;
pharmacology;
Succinates;
chemistry;
pharmacology;
Sulfur Compounds;
chemistry;
pharmacology;
Triterpenes;
chemistry;
pharmacology;
Virus Assembly;
drug effects;
Virus Release;
drug effects;
Virus Replication;
drug effects;
physiology;
gag Gene Products, Human Immunodeficiency Virus;
metabolism;
physiology
- From:
Acta Pharmaceutica Sinica
2010;45(2):205-214
- CountryChina
- Language:Chinese
-
Abstract:
The late stages of the HIV-1 replication cycle are important to the overall replication cycle. During the late stages, HIV-1 replication undergoes the processes of assembly, release, and maturation, resulting in the production of a mature virus particle capable of infecting a new target cell. The structural protein Gag and its related gene (protein) play a central role in these pathways. The different regions of Gag worked in concert to drive production of a mature infectious particle through protein-protein, protein-RNA and protein-lipid interactions. The designed drug aimed directly at these stages can efficiently block the maturation and infectivity of HIV-1. In this article, the role of structural protein Gag and related gene (protein) in late stages of the HIV-1 replication cycle and related inhibitors is reviewed.
