In vitro pharmacodynamics study of an anti-HIV Chinese herbal formulation.
- Author:
Ze-lin LI
1
;
Yue ZENG
;
Li-shan SU
;
Xiao-mei ZHANG
;
Yi-ming SHAO
;
Xin ZENG
;
Hans WOLF
;
Yi ZENG
Author Information
1. Beijing Century Health Pharmaceutical Technology Development Co., Ltd., Beijing 100021, China. zl_li@hotmail.com
- Publication Type:Journal Article
- MeSH:
Anti-HIV Agents;
isolation & purification;
pharmacology;
Cells, Cultured;
virology;
Drug Combinations;
Drug Resistance, Viral;
Drug Synergism;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
HIV Protease Inhibitors;
pharmacology;
HIV-1;
drug effects;
physiology;
Humans;
Inhibitory Concentration 50;
Plants, Medicinal;
chemistry;
Scutellaria;
chemistry;
Virus Replication;
drug effects;
Zidovudine;
pharmacology
- From:
Acta Pharmaceutica Sinica
2010;45(2):253-256
- CountryChina
- Language:Chinese
-
Abstract:
AIDS caused by HIV-1, is a major threat to human being. An anti-HIV formulation from Chinese herbs, so called "Qu Du Zeng Ning", have been recently developed. In this work, the pharmacodynamics of the formulation in vitro was studied. The results showed that Qu Du Zeng Ning inhibit the replication of HIV-1 efficiently in all cell-based assay, with IC50 at 105.2, 70.7, 77.4 microg mL(-1), separately. A significant synergy between the formulation and zidovudine (AZT) was observed, and it also showed a potent activity against HIV-1 drug-resistant mutant.
