Design, synthesis of quinolinone acid-containing compounds with anti-HIV integrase activity.
- Author:
Xiao-fang CHEN
1
;
Yan-bin WU
;
Jie JIN
;
Rui-zhen WANG
;
Chong WANG
;
Jun LIU
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
HIV Integrase;
metabolism;
HIV Integrase Inhibitors;
chemical synthesis;
chemistry;
pharmacology;
Inhibitory Concentration 50;
Quinolones;
chemical synthesis;
chemistry;
pharmacology;
Structure-Activity Relationship
- From:
Acta Pharmaceutica Sinica
2010;45(2):263-267
- CountryChina
- Language:Chinese
-
Abstract:
A series of novel quinolinone acid-containing compounds were designed and synthesized. Their structures were confirmed with 1H NMR and MS. The target compounds were tested for anti-HIV-1 integrase activities in vitro with enzyme linked immunosorbent assay (ELISA). The result showed that D-2, D-4 and D-7 have anti-integrase activity with IC50 < 100 micromol L(-1).
