Synthesis and photochemical virus inactivation of novel phenothiazines.
- Author:
Hui WEN
1
;
Xiao-Fang WANG
;
Yi HUANG
;
Jing-Xing WANG
;
Guang-Zhong YANG
Author Information
1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Antiviral Agents;
chemical synthesis;
pharmacology;
Methylene Blue;
analogs & derivatives;
chemistry;
Phenothiazines;
chemical synthesis;
pharmacology;
Photosensitizing Agents;
chemical synthesis;
Structure-Activity Relationship;
Virus Inactivation;
drug effects
- From:
Acta Pharmaceutica Sinica
2010;45(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Virus inactivation with photochemistry is being suitable for blood or blood products, methylene blue (MB)/light treatment has been used for viral inactivation of cellular blood components. Twelve new phenothiazines derivatives were designed and synthesized, and were used to test viral inactivation and red cell damage preliminary. Results showed that compound YWW-7 has a satisfactory activity, it could be developed as a new viral inactivation agent for blood products.
