Research progress of anti-influenza virus agents.
- Author:
Qiang ZHANG
1
;
Qing-jie ZHAO
;
Rui-sheng XIONG
;
Jian-feng LI
;
Jing-shan SHEN
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Amantadine;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Antiviral Agents;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Cyclopentanes;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Guanidines;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Humans;
Indoles;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Influenza, Human;
drug therapy;
Neuraminidase;
antagonists & inhibitors;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Orthomyxoviridae;
drug effects;
Oseltamivir;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Pyrrolidines;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Rimantadine;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Structure-Activity Relationship;
Viral Matrix Proteins;
antagonists & inhibitors;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use;
Zanamivir;
chemical synthesis;
chemistry;
pharmacology;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2010;45(3):289-299
- CountryChina
- Language:Chinese
-
Abstract:
Influenza is a major threat to millions of people worldwide. Vaccines and antiviral agents are two main options available to reduce the impact of the influenza virus, while anti-influenza agents are the most effective means to prevent the transmission of the highly contagious virus and to treat the epidemics of disease. At present, four anti-influenza agents have been approved by the FDA for the treatment of influenza, including two M2 protein ion channel inhibitors-amantadine and rimantadine and two neuraminidase inhibitors-zanamivir and oseltamivir. Arbidol hydrochloride, launched in Russia, is a potent inhibitor of influenza virus, too. Neuraminidase inhibitors could be classified generally by structure into six different kinds: sialic acid derivatives, benzoic acid derivatives, cyclohexene derivatives, cyclopentane derivatives, pyrrolidine derivatives and natural products. In this paper, recent progress in the research of the action mechanisms and structure-activity relationships of these anti-influenza virus agents were reviewed.
