Simultaneous determination of 56 organochlorine and pyrethroid pesticides in traditional Chinese medicines by GC coupled with dual-tower and dual-column.
- Author:
Zheng-wei JIA
1
;
Xiu-hong MAO
;
Shui MIAO
;
Ji-wei LU
;
Ke CHEN
;
Ke WANG
;
Shen JI
Author Information
1. Department of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, Gas;
methods;
Chromatography, Gel;
Drug Contamination;
Drugs, Chinese Herbal;
chemistry;
Hydrocarbons, Chlorinated;
analysis;
Limit of Detection;
Pesticide Residues;
analysis;
Pyrethrins;
analysis;
Reproducibility of Results;
Solid Phase Extraction
- From:
Acta Pharmaceutica Sinica
2010;45(3):353-358
- CountryChina
- Language:Chinese
-
Abstract:
The paper is to report the establishment of a method for the determination of multi-residue organochlorine and pyrethroid pesticides in traditional Chinese medicines (TCMs). Fifty-six pesticides were extracted by high-speed homogenization, and then purified through gel permeation chromatography (GPC) and solid phase extraction (SPE) cartridges. The residues were simultaneously identified and quantified by GC-ECD equipped with dual tower, dual column and two micro-ECD detectors. The analytical performance was demonstrated by the analysis of 3 TCMs samples' extracts, spiked at three concentration levels for each pesticide. In general, the recoveries ranging from 70% to 110%, with relative standard deviations (RSDs) better than 15%, were obtained. The limit of detection (LOD) for most of the targeted pesticides tested was below 0.01 mg kg(-1). The method had good extraction efficiency, purification effect and good reproducibility, which could be applied to the determination of organochlorine and pyrethroid pesticide residues in the routine analysis of TCMs.
