Preparation of polyelectrolyte microcapsules contained gold nanoparticles.
- Author:
Ya-jie SUN
1
;
Jia-bi ZHU
;
Chun-li ZHENG
Author Information
1. Pharmaceutical Research Institute, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Calcium Carbonate;
chemistry;
Capsules;
Drug Carriers;
Drug Delivery Systems;
methods;
Electrolytes;
chemistry;
Fluorescein-5-isothiocyanate;
analogs & derivatives;
chemistry;
Gold;
chemistry;
Microscopy, Electron, Scanning;
Microscopy, Fluorescence;
Nanoparticles;
Particle Size;
Serum Albumin, Bovine;
chemistry
- From:
Acta Pharmaceutica Sinica
2010;45(3):371-375
- CountryChina
- Language:Chinese
-
Abstract:
In this work, polyelectrolyte microcapsules containing gold nanoparticles were prepared via layer by layer assembly. Gold nanoparticles and poly (allyamine hydrochloride) (PAH) were coated on the CaCO3 microparticles. And then EDTA was used to remove the CaCO3 core. Scanning electron microscopy (SEM) was used to characterize the surface of microcapsules. SEM images indicate that the microcapsules and the polyelectrolyte multilayer were deposited on the surface of CaCO3 microparticles. FITC-bovine serum albumin (FITC-BSA, 2 mg) was incorporated in the CaCO3 microparticles by co-precipitation. Fluorescence microscopy was used to observe the fluorescence intensity of microcapsules. The encapsulation efficiency was (34.31 +/- 2.44) %. The drug loading was (43.75 +/- 3.12) mg g(-1).
