In vitro and in vivo anti-influenza virus activity of ribavirin injection.
- Author:
Rong-mei GAO
1
;
Xing-qiong LI
;
Wei-ying HE
;
Jian-dong JIANG
;
Yu-huan LI
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antiviral Agents;
administration & dosage;
pharmacology;
therapeutic use;
Cell Line;
Cytopathogenic Effect, Viral;
drug effects;
Dogs;
Female;
Influenza A Virus, H1N1 Subtype;
drug effects;
Influenza A Virus, H3N2 Subtype;
drug effects;
Influenza B virus;
drug effects;
Injections;
Lung;
pathology;
Mice;
Orthomyxoviridae Infections;
drug therapy;
pathology;
Ribavirin;
administration & dosage;
pharmacology;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2010;45(3):403-407
- CountryChina
- Language:Chinese
-
Abstract:
Ribavirin is a broad-spectrum inhibitor against several unrelated DNA or RNA viruses in vitro and in vivo. In this paper the in vitro and in vivo study of anti-influenza virus activity of ribavirin (RBV) injection had been reported. The in vitro antiviral activity of ribavirin injection against influenza virus A and B was studied by CPE. The in vivo protective action of ribavirin injection against influenza A/FM/1/47(H1N1) mouse adapted strain infected mouse was studied with mouse model. The results showed ribavirin injection has strong inhibitory activity against 7 virus strains tested in vitro. Ribavirin injection could significantly increase virus infected mouse survival rate and survival days and improve lung pathogen and lung index.
