Progress in the study of tubulin inhibitors.
- Author:
Hai SHANG
1
;
Li PAN
;
Shu YANG
;
Hong CHEN
;
Mao-sheng CHENG
Author Information
1. Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemical synthesis;
chemistry;
pharmacology;
Humans;
Microtubules;
drug effects;
metabolism;
Mitosis;
drug effects;
Molecular Structure;
Neoplasms;
drug therapy;
Stilbenes;
chemical synthesis;
chemistry;
pharmacology;
Structure-Activity Relationship;
Tubulin;
metabolism;
Tubulin Modulators;
chemical synthesis;
chemistry;
pharmacology
- From:
Acta Pharmaceutica Sinica
2010;45(9):1078-1088
- CountryChina
- Language:Chinese
-
Abstract:
Microtubule is one of the key components of the cytoskeleton and plays an important role in the maintenance of cell shape and the process of signal transduction and mitosis. Due to the extreme importance of microtubule in the process of mitosis, tubulin becomes one of the most important targets for development of new anticancer drugs and tubulin inhibitors are used for the treatment of cancer nowadays. These inhibitors have antitumor activity by inhibiting or promoting the assembly of tubulin to microtubules and interfering the process of cell mitosis. This review summarized the research progress of the tubulin inhibitors, especially the introduction of the tubulin inhibitors of pharmacological activities and the progress of clinical research. Also, the development trend of these inhibitors is discussed.
