Pre-Core mutation of HBV among 26 families with history of chronic HBV infection in Shenyang.
- Author:
Zhiwei LI
1
;
Xiaoguang DOU
;
Pei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Child; China; epidemiology; Female; Genes, Viral; genetics; Hepatitis B virus; genetics; Hepatitis B, Chronic; epidemiology; virology; Humans; Male; Middle Aged; Point Mutation; Polymorphism, Restriction Fragment Length
- From: Chinese Journal of Experimental and Clinical Virology 2002;16(3):239-241
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the Pre-Core mutations of HBV and clinical significance among families with history of chronic HBV infection.
METHODSThe G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was detected by PCR-RFLP.
RESULTSThe results showed that the mutation rate of G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA was much higher in patients (56.3%) and their family members (40.5%) than in their spouses (25.0%). While the positive rate of anti-HBs in their spouses were 26.3%. On the other hand those mutations were much higher in chronic hepatitis B patients (52.4%) and HBV carriers (44.4%) than in chronic severe hepatitis B patients (20.0%).
CONCLUSIONSThe G to A mutation at nucleotide 1896 in the pre C gene of HBV DNA could be associated with persistent HBV infection.
