Effect of D-cellobiose on oral bioavailability of gentiopicroside.

Author: Yun-Hao DAI ¹ ; Man WANG ² ; Ya-Nan ZHU ¹ ; Lu-Lu WANG ² ; Jian-Ming JU ¹ ; Zhen-Hai ZHANG ¹
Author Information

1. Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210000, China.
2. Anhui University of Chinese Medicine, Hefei 230031, China.
Publication Type:Journal Article
Keywords: D-cellobiose; gentiopicroside; oral absorption; β-glucosidase
From: China Journal of Chinese Materia Medica 2016;41(10):1855-1859
CountryChina
Language:Chinese
Abstract: In this study, the effect of D-cellobiose on oral bioavailability of gentiopicroside (GPS) was investigate. The influence of D-cellobiose on GPS was achieved by calculating the residual GPS after being degraded with β-glucosidase or intestinal flora, and the data demonstrated D-cellobiose could inhibit the degradation of GPS in intestines; in bioavailability experiment, D-cellobiose could significantly improve the oral bioavailability (P<0.05) of GPS at the mass ratio of 1∶5, 1∶10 (GPS-D-cellobiose). D-cellobiose applied in this study may improve the oral bioavailability of GPS through delaying the degradation in intestines.