Hypoglycemic and hypolipidemic effects of quercetin and its glycosides.
- Author:
Shu-xia YAN
;
Xian LI
;
Chong-de SUN
;
Kun-song CHEN
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Glycosides;
chemistry;
pharmacology;
Humans;
Hyperlipidemias;
drug therapy;
metabolism;
Hypoglycemia;
drug therapy;
metabolism;
Hypoglycemic Agents;
chemistry;
pharmacology;
Hypolipidemic Agents;
chemistry;
pharmacology;
Quercetin;
chemistry;
pharmacology
- From:
China Journal of Chinese Materia Medica
2015;40(23):4560-4567
- CountryChina
- Language:Chinese
-
Abstract:
Quercetin and its glycosides are important flavonols in traditional herbal drugs and plant-derived food, and they have diverse hiological activities such as antioxidant, anticarcinogenic, anti-inflammatory, hypoglycemic and hypolipidemic activities. Numerous studies have demonstrated that quercetin and its glycosides were effective in the prevention and treatment of non-infectious chronic disease such as diabetes, obesity, and hyperlipidemia. They can regulate glucose and lipid metaholism through different mechanisms. They can decrease blood glucose via protecting pancreatic/p cells or/and improving insulin sensitivity. Also, they have lipid-lowering effects, which may be the result of regulation of lipid catabolism or/and anabolism. Their distributions, as well as the hypoglycemic and hypolipidemic effects are reviewed in this paper. In addition, further bioactivities as well as their dose-activity relationship, structure-activity relationship, bioavailability, and future clinical application of quercetin and its glycosides are discussed and proposed.
