Assessment of biochemical and antioxidative status in patients suffering from dengue fever.
10.1007/s11596-015-1446-x
- Author:
Mahmood RASOOL
1
;
Arif MALIK
;
Khalid Mahmud KHAN
;
Muhammad Saeed QURESHI
;
Beenish SHABBIR
;
Sara ZAHID
;
Muhammad ASIF
;
Abdul MANAN
;
Sana RASHID
;
Saima Rubab KHAN
;
Hafiz Muhammad ARSALAN
;
Rabail ALAM
;
Mahwish AROOJ
;
Mahmood Husain QAZI
;
Adeel Gulzar Ahmed CHAUDHARY
;
Adel Mohammed ABUZENADAH
;
Mohammed Hussain AL-QAHTANI
;
Sajjad KARIM
Author Information
1. Center of Excellence in Genomic Medicine Research, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia, mahmoodrasool@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Adult;
Antioxidants;
metabolism;
Biomarkers;
blood;
China;
Dengue;
classification;
diagnosis;
metabolism;
Diagnosis, Differential;
Female;
Humans;
Immunoglobulin M;
metabolism;
Male;
Middle Aged;
Young Adult
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(3):411-418
- CountryChina
- Language:English
-
Abstract:
A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever (DF) by evaluating biochemical and oxidative status of patients. ELISA IgM antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) showed significant difference. Significant increases in serum alanine amino transferase (ALT) (P=0.000), aspartate amino transferase (AST) (P=0.000), alkaline phosphatase (ALP) (P=0.000), malondialdehyde (MDA) along with significant decreases in total protein (TP) (P=0.000), reduced glutathione (GSH) (P=0.000), superoxide dismutase (SOD), catalase (CAT) (P=0.000), and sialic acid contents (P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants (r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.
