Prodynorphin gene promoter polymorphism and temporal lobe epilepsy: A meta-analysis.
10.1007/s11596-015-1482-6
- Author:
Na ZHANG
1
;
Tao-hui OUYANG
2
;
Qing ZHOU
3
;
Hui-cong KANG
3
;
Sui-qiang ZHU
4
Author Information
1. Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. hustzhangna@163.com.
2. Department of Neurosurgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
3. Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
4. Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China. zhusuiqiang@163.com.
- Publication Type:Journal Article
- Keywords:
genetics;
meta-analysis;
polymorphism;
prodynorphin;
temporal lobe epilepsy
- MeSH:
Case-Control Studies;
Enkephalins;
genetics;
Epilepsy, Temporal Lobe;
diagnosis;
genetics;
pathology;
Family;
Gene Expression;
Genetic Association Studies;
Genetic Predisposition to Disease;
Humans;
Inheritance Patterns;
Odds Ratio;
Polymorphism, Genetic;
Prognosis;
Promoter Regions, Genetic;
Protein Precursors;
genetics
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(5):635-639
- CountryChina
- Language:English
-
Abstract:
Previous studies have reported the association of prodynorphin (PDYN) promoter polymorphism with temporal lobe epilepsy (TLE) susceptibility, but the results remain inconclusive. To further precisely evaluate this association, we performed a meta-analysis. Published studies of TLE and PDYN polymorphism up to February 2015 were identified. Subgroup analysis by TLE subtype was performed. Moreover, sensitivity, heterogeneity, and publication bias were also analyzed. Seven case-control studies were finally included in this meta-analysis with 875 TLE cases and 1426 controls. We did not find synthetic evidence of association between PDYN promoter polymorphism and TLE susceptibility (OR=1.184, 95% CI: 0.873-1.606, P=0.277). Similar results were also obtained in non-familial-risk TLE subgroup. However, in the familial-risk TLE subgroup analysis, a significant association was observed (OR=1.739, 95% CI: 1.154-2.619, P=0.008). In summary, this meta-analysis suggests that PDYN gene promoter polymorphism might contribute to familial-risk TLE.
