Biventricular repair versus uni-ventricular repair for pulmonary atresia with intact ventrical septum: A systematic review.
10.1007/s11596-015-1485-3
- Author:
Fei-fei LI
1
;
Xin-ling DU
2
;
Shu CHEN
3
Author Information
1. Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. lifeifei0828@aliyun.com.
2. Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
3. Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. shu_chen@hust.edu.cn.
- Publication Type:Journal Article
- Keywords:
biventricular repair;
overall survival;
pulmonary atresia with intact ventricular septum;
systematic review;
uni-ventricular repair
- MeSH:
Arrhythmias, Cardiac;
physiopathology;
prevention & control;
Cardiac Valve Annuloplasty;
methods;
mortality;
Fontan Procedure;
methods;
mortality;
Heart Defects, Congenital;
mortality;
pathology;
surgery;
Heart Ventricles;
abnormalities;
pathology;
surgery;
Humans;
Pulmonary Atresia;
mortality;
pathology;
surgery;
Retrospective Studies;
Survival Analysis;
Treatment Outcome
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2015;35(5):656-661
- CountryChina
- Language:English
-
Abstract:
The management of pulmonary atresia with intact ventricular septum (PA/IVS) remains controversial. The goal of separating systematic and pulmonary circulation can be achieved by biventricular or uni-ventricular (Fontan or one and a half ventricle repair) strategies. Although outcomes have been improved, these surgical procedures are still associated with high mortality and morbidity. An optimal strategy for definitive repair has yet to be defined. We searched databases for genetically randomized controlled trials (RCTs) comparing biventricular with uni-ventricular repair for patient with PA/IVS. Data extraction and quality assessment were performed following the guidelines of the Cochrane Collaboration. Primary outcome measures were overall survival, and secondary criteria included exercise function, arrhythmia-free survival and treatment-related mortality. A total number of 669 primary citations were screened for relevant studies. Detailed analysis revealed that no RCTs were found to adequately address the research question and no systematic meta-analysis would have been carried out. Nevertheless, several retrospective analyses and case series addressed the question of finding right balance between biventricular and uni-ventricular repair for patient with PA/IVS. In this review, we will discuss the currently available data.
