Clinical efficacy and safety of sublingual immunotherapy using standardized dermatophagoides farinae extract for children with combined allergic rhinitis and asthma syndrome
10.3760/cma.j.issn.1673-0860.2011.05.010
- VernacularTitle:舌下粉尘螨滴剂治疗儿童支气管哮喘伴变应性鼻炎的有效性和安全性
- Author:
Chi-Jun WEN
1
;
Ming-Feng ZHU
;
Wen-Mei REN
;
Xiao-Ying LIU
;
Hong QIAN
Author Information
1. 上海市第二人民医院
- Keywords:
Asthma;
Rhinitis,allergic,perennial;
Dermatophagoides farinae;
Desensitization,immunologic
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(5):393-396
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of sublingual immunotherapy using standardized dermatophagoides farinae extract for children with combined allergic rhinitis and asthma syndrome. Methods Fifty-two children, from 4 to 14 years of age, with mite-sensitive combined allergic rhinitis and asthma syndrome were treated sublingually with standardized dermatophagoides farinae extract. The clinical efficacy was evaluated by monthly follow-up visits. After treatment for 1 or 2 years using the standardized dermatophagoides farinae extract, the asthma and rhinitis symptom scores, medication scores and adverse reactions before and after treatment were evaluated. SPSS 17.0 software was used to analyze the data. Results The allergic asthma symptom scores before treatment during the day were 3. 22 ±0. 66 and at night 2.05 ±0. 57. After 1 year of treatment, the day and night scores ( 1. 68 ± 0. 61 , 0. 94 ± 0. 32) respectively, were decreased significantly (q values were 15. 25 and 13. 78 respectively, all P < 0. 01 ). After 2 years of treatment, the scores (0. 61 ± 0. 28, 0. 43 ±0. 13 ) were also decreased significantly ( q values were 10. 29 and 6. 07 respectively, all P < 0. 01 ). The allergic rhinitis symptom scores and medication scores were 2. 34 ± 0. 59 and 3. 09 ±1.01 respectively before treatment and 1.21 ± 0. 46 and 1. 89 ±0. 64 after 1 year of treatment. The differences were significant ( q values were 15. 48 and 18. 61 respectively, all P<0.01). The allergic rhinitis symptom scores and medication scores were 1.02 ±0.37 and 1.49 ± 0. 38 after 2 years of treatment. There was no significant difference between 2 years of treatment and 1 year of treatment(q values were 2.53 and 2.78 respectively, all P >0.05). There were no severe adverse events during the treatment, except for mild mouth cavity discomfort. Conclusions Suhlingual immunotherapy using standardized dermatophagoides farinae extract is safe and effective in the treatment ofchildren with combined allergic rhinitis and asthma syndrome.
