Management of oral mucositis in patients with head and neck cancer receiving chemoradiotherapy and/or molecular targeted therapy
10.3760/cma.j.issn.1673-0860.2011.06.014
- VernacularTitle:头颈部鳞癌患者同步放化疗和(或)分子靶向治疗继发口腔黏膜炎的防治
- Author:
Xin-Xin ZHANG
1
;
Lin MA
;
Jia-Ling WANG
;
Wen-Ming WU
;
Lin-Chun FENG
;
De-Liang HUANG
Author Information
1. 解放军总医院
- Keywords:
Combined modality therapy;
Head and neck neoplasms;
Carcinoma,squamous cell;
Stomatitis;
Quinolones
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(6):505-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence and treatment of oral mucositis caused by concurrent chemoradiotherapy and/or molecular targeted therapy in the patients with advanced squamous cell carcinoma of the head and neck. Methods A retrospective study of the incidence and treatment of oral mucositis was performed in 179 patients (155 male and 24 female; 124 patients at stage Ⅲ and 55 patients at stage Ⅳ) receiving concurrent chemotherapy and (or) molecular targeted therapy between November 2007 and November 2010. Grade Ⅰ , Ⅱ , Ⅲ and Ⅳ oral mucositis occurred respectively in 49, 50, 67 and 13 patients. All the patients received oral mucositis prophylaxis. After the occurrence of oral mucositis, conventional treatment of mucositis combined with quinolone antibiotics were applied. Results Of the patients, 99 patients with grade Ⅰ or Ⅱ and 4 patients with grade Ⅲ oral mucositis were effectively managed by conventional treatment; 76 patients with grade Ⅲ or Ⅳ oral mucositis were also significantly controled by conventional treatment plus antibiotics. After the treatments, all patients with oral mucositis were under control, with the decrease in the grade of oral mucositis, the reduction of oral pain and the improvement in ability to eat None of them had radiation treatment breaks. Conclusions Combined modality therapy can effectively control chemoradiation-induced oral mucositis in patients with head and neck squamous cell carcinoma, grade Ⅰ and Ⅱ oral mucositis were cured by conventional treatment and quinolone antibiotics play a key role in the treatmeats for grade Ⅲ and Ⅳ oral mucositis.
