Relationship between genetic polymorphism of tumor necrosis factor-alpha and susceptibility to intrauterine HBV infection.
- Author:
Shao-Qing GU
1
;
Qi-Rong ZHU
;
Hui YU
;
Lin-E FEI
;
Zuo-Quan DONG
;
Dong-Po PU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Child; Disease Susceptibility; Female; Hepatitis B; transmission; Humans; Infant; Infectious Disease Transmission, Vertical; Polymorphism, Genetic; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; genetics
- From: Chinese Journal of Hepatology 2004;12(9):538-539
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possible relationship between tumor necrosis factor (TNF)-alpha-238G/A gene polymorphism and the susceptibility to intrauterine HBV infection.
METHODSTwo hundred and fifty-six children, including 130 infants born to HBsAg positive mothers were divided into two groups: forty-five children with intrauterine HBV infection (group I) and 85 children without intrauterine HBV infection (group II), with a control group of 126. TNF-alpha-238G/A gene polymorphism was examined in all 256 children, by means of real-time quantitative fluorescent PCR.
RESULTSA significant difference of TNF-alpha-238A allele frequency was found between group I and group II (x2=6.797, P=0.009), and between group I and the controls group (x2=0.047, P=0.002), but there was no significant difference between group II and the control groups (x2=0.047, p=0.828).
CONCLUSIONThis study found that genetic polymorphism of tumor necrosis factor-a was associated with intrauterine HBV infection
