Expression of type I inositol 1,4,5-triphosphate receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis.
- Author:
Jing-yan WANG
1
;
Hong-yan LIU
;
Pei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arterioles; metabolism; Calcium Channels; biosynthesis; genetics; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Inositol 1,4,5-Trisphosphate Receptors; Kidney; metabolism; Kidney Glomerulus; blood supply; metabolism; Liver Cirrhosis, Experimental; chemically induced; complications; metabolism; Male; Random Allocation; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; biosynthesis; genetics; Renal Artery; metabolism
- From: Chinese Journal of Hepatology 2004;12(10):609-611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of type I inositol 1,4,5-triphosphate receptor in rat glomerular and afferent arterioles in a model of liver cirrhosis and study the role of cross-membrane message transduction in the pathogenesis of hepatorenal syndrome.
METHODSIn a rat model of carbontetrachloride liver cirrhosis, the expression of type I inositol 1,4,5-triphosphate receptor (IP3R) on glomerular and afferent arterioles was measured by immunohistochemical method.
RESULTSIn the experimental group, 30 rats were used to make a model of liver cirrhosis. 11 rats survived during the experiment. The expression of type I IP3R on glomerular and afferent arterioles was 4.97+/-1.34 and 4.09+/-1.14 in the liver cirrhosis group, and it was 2.43+/-1.67 and 1.83+/-1.32 in the normal control rats. The differences between these two groups are statistically significant (t = 2.28, P = 0.0458).
CONCLUSIONExpression of type I IP3 receptor on rat glomerular and afferent arterioles in a model of liver cirrhosis indicated that the mechanism of cross-membrane message transduction plays a very important role in the pathogenesis of hepatorenal syndrome.
