Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur..
- Author:
Xiao-Feng SUN
1
;
Shu-Juan WEN
;
Hui LI
;
Jin-Lin HOU
;
Yue-Xin ZHANG
;
Zhan-Hui WANG
;
Yu-Jian ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; virology; Genotype; Hepatitis B virus; genetics; Hepatitis B, Chronic; virology; Humans; Liver Neoplasms; virology
- From: Chinese Journal of Hepatology 2009;17(2):88-90
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.
METHODSThe HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.
RESULTSTwo HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
CONCLUSIONIn Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
