Synergistic effect of zinc and vitamin A on T cell functions.
- Author:
Ting-Xin LI
1
;
Yun LI
Author Information
- Publication Type:Journal Article
- MeSH: Apoptosis; drug effects; Cell Cycle; drug effects; Cell Proliferation; drug effects; Cells, Cultured; Drug Synergism; Humans; T-Lymphocytes; drug effects; Vitamin A; pharmacology; Zinc; pharmacology
- From: Biomedical and Environmental Sciences 2007;20(2):131-134
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo determine whether supplementation of zinc and vitamin A may improve the function of T cells in human PBMC.
METHODST cells were separated and cultured in vitro, supplemented with either Zn or vitamin A alone, or both Zn and vitamin A (10(-6) mol/L, 10(-5) mol/L, 10(-4) mol/L). After harvesting, cell proliferation, cell cycle, apoptosis, expression or function of cell-surface molecules, such as CD3+, CD4+, and CD8+ were detected.
RESULTSHigher proliferation level and lower apoptosis level were observed in cells supplemented with both Zn and vitamin A, showing the strongest effect (P < 0.05). Zn-supplement increased the CD4+/CD3+ cell percentage, and simultaneously decreased the CD8+/CD3+ cell population. VA-supplement showed the opposite effect in comparison with Zn-supplement.
CONCLUSIONT-cell function can be improved, depending on the zinc and/or vitamin A supplemented.
