Evaluation of Osseointegration in Dense Ceramics Using Rabbit's External Fixation Model.
- Author:
Jae Hyup LEE
1
;
Dong Ho LEE
;
Jae Hag LEE
;
Hyun Sik GONG
;
Young Joon AHN
;
Hyun Seung RYU
;
Jun Hyuk SEO
;
Kug Sun HONG
;
Hwan KIM
;
Bong Soon CHANG
;
Choon Ki LEE
Author Information
1. Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea. choonki@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Cerabone(R)-AW;
CaO-SiO2- B2O3 glass-ceramics;
Osseointegration;
Bioactive glass ceramics;
Bone replacement material
- MeSH:
Bone Substitutes;
Ceramics*;
External Fixators;
Glass;
Humans;
Male;
New Zealand;
Osseointegration*;
Rabbits;
Solubility;
Tibia
- From:Journal of Korean Orthopaedic Research Society
2003;6(2):151-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the osseointegration of different dense ceramics. MATERIALS AND METHODS: Twenty-eight New Zealand white male rabbits were divided into 4 groups by implant materials: Cerabone(R)-AW, CaO-SiO2- B2O3 glass ceramics (CS10B), CaO-SiO2- B2O3 glass (CS5B glass) and Cerabone(R)- A W + A l2O3 glass ceramics. We implanted the dense ceramics into the tibia of rabbits with external fixator and checked the radiographs every 4 weeks. The union rate, histology and SEM were evaluated 8 weeks after surgery. RESULTS: The union rates were 85.7% (6 of 7) in Cerabone(R)-AW, 85.7% (6 of 7) in CS10B, 71.4% (5 of 7) in CS5B glass and 28.6% (2 of 7) in Cerabone(R)-AW+Al2O3 by simple radiographs. The union rates of Cerabone (R)-AW and CS10B were statistically higher than that of Cerabone(R)-AW+Al2O3 (p=0.031). Histologically, the Cerabone(R)-AW had fused with tibia without biodegradation, CS10B, CS5B glass had fused with tibia in some portion but resorbed in others. Cerabone(R)-AW+Al2O3 had not fused with bony tissue. CONCLUSION: We confirmed the osseointegration and insolubility of Cerabone(R)-AW. We also confirmed the osseointegration and partial solubility of CaO-SiO2-B2O3 glass ceramics. These findings suggest that Cerabone (R)-AW can be used as an insoluble artificial bone and CaO-SiO2-B2O3 glass ceramics as biodegradable bone replacement materials.
