Application of benchmark dose (BMD) in estimating biological exposure limit (BEL) to cadmium.
- Author:
Bo SHAO
1
;
Tai-Yi JIN
;
Xun-Wei WU
;
Qing-Hu KONG
;
Ting-Ting YE
Author Information
- Publication Type:Journal Article
- MeSH: Acetylglucosaminidase; urine; Albuminuria; urine; Biomarkers; urine; Cadmium; toxicity; urine; Dose-Response Relationship, Drug; Female; Humans; Male; Occupational Exposure; Spectrophotometry, Atomic; beta 2-Microglobulin; urine
- From: Biomedical and Environmental Sciences 2007;20(6):460-464
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo estimate the biological exposure limit (BEL) using benchmark dose (BMD) based on two sets of data from occupational epidemiology.
METHODSCadmium-exposed workers were selected from a cadmium smelting factory and a zinc product factory. Doctors, nurses or shop assistants living in the same area served as a control group. Urinary cadmium (UCd) was used as an exposure biomarker and urinary beta2-microgloburin (B2M), N-acetyl-13-D-glucosaminidase (NAG) and albumin (ALB) as effect biomarkers. All urine parameters were adjusted by urinary creatinine. Software of BMDS (Version 1.3.2, EPA.U.S.A) was used to calculate BMD.
RESULTSThe cut-off point (abnormal values) was determined based on the upper limit of 95% of effect biomarkers in control group. There was a significant dose response relationship between the effect biomarkers (urinary B2M, NAG; and ALB) and exposure biomarker (UCd). BEL value was 5 microg/g creatinine for UB2M as an effect biomarker, consistent with the recommendation of WHO. BEL could be estimated by using the method of BMD. BEL value was 3 microg/g creatinine for UNAG as an effect biomarker. The more sensitive the used biomarker is, the more occupational population will be protected.
CONCLUSIONBMD can be used in estimating the biological exposure limit (BEL). UNAG is a sensitive biomarker for estimating BEL after cadmium exposure.
