Relationship between transforming growth factor-alpha gene polymorphism and non-syndromic cleft lip with cleft palate.
- Author:
Kui-feng YUAN
1
;
Qing-guo LAI
;
De-ren LI
;
Zhong-jun YANG
;
Xiao-hong ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Cleft Lip; Cleft Palate; Gene Frequency; Genotype; Humans; Polymerase Chain Reaction; Polymorphism, Genetic; Transforming Growth Factor alpha
- From: West China Journal of Stomatology 2006;24(6):533-535
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association of TGF-alpha gene polymorphism and non-syndromic cleft lip with cleft palate in Shandong province.
METHODSPolymerase chain reaction combined with restrict enzyme digestion was used to detect the target gene variation in 98 patients with non-syndromic cleft lip with cleft palate and 101 healthy controls.
RESULTSThe C2 allele frequency in patients with non-syndromic cleft lip with cleft palate was significantly higher than that in healthy controls. The genotype frequency in patients with positive family history was significantly higher than that without positive family history.
CONCLUSIONTGF-alpha gene polymorphism is closely associated with non-syndromic cleft lip with cleft palate in Shandong, especially in patients with positive family history.
