Expression and significance of hypoxia inducible factor-1alpha in buccal carcinoma.

Author: Bo HAN ¹ ; Long-jiang LI ; Wei DAI
Author Information

1. Dept. of Head and Neck Tumor Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
Publication Type:Journal Article
MeSH: Aged; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lymphatic Metastasis; Middle Aged; Mouth Neoplasms; Prognosis
From: West China Journal of Stomatology 2007;25(1):5-7
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the expression of hypoxia inducible factor-1alpha (HIF-1alpha) protein in buccal carcinoma and its biological significance.
METHODSThe expression of HIF-1alpha was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1alpha and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test.
RESULTSThe positive rate of HIF-1alpha was higher in T3-4 than T1-2, and the positive rate of HIF-1alpha was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1alpha over-expression had poor prognosis than patients with HIF-1alpha lower expression.
CONCLUSIONOver-expression of HIF-1alpha is a vital biological marker in prognosis of buccal cancer.