Expression of inducible nitric oxide synthase in cartilage in progression of temporomandibular joint osteoarthritis.
- Author:
Zhan-wei GAO
1
;
Da-zhang WANG
;
Bao-lin LIU
;
Hai-huan MA
Author Information
- Publication Type:Journal Article
- MeSH: Cartilage; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoarthritis; Temporomandibular Joint
- From: West China Journal of Stomatology 2007;25(3):216-218
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of inducible nitric oxide synthase (iNOS) in cartilage of temporomandibular joint osteoarthriti (TMJOA), and to evaluate the role of iNOS in the progression of TMJOA.
METHODSThe goats were used and TMJOA was induced by injection of collagenase in upper joint space. The joints were obtained and were investigated by using immunohistochemistry at 2, 4, 12, 24 weeks after injection.
RESULTSAlmost no expression of iNOS in normal cartilage of TMJ. In the diseased joints, strong or definite iNOS reactivity was expressed.
CONCLUSIONiNOS plays an important role in the progression of TMJOA.
