Diffuse large B-cell lymphoma presenting with extensive cutaneous infiltration.
- Author:
Norashikin SHAMSUDIN
1
;
Choong Chor CHANG
Author Information
1. Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia. aliffarhan@yahoo.com
- Publication Type:Case Reports
- MeSH:
Female;
Humans;
Lymphoma, Large B-Cell, Diffuse;
complications;
drug therapy;
pathology;
Middle Aged;
Pancytopenia;
etiology;
Pruritus;
etiology;
Skin Neoplasms;
complications;
drug therapy;
pathology;
secondary
- From:Singapore medical journal
2012;53(9):e198-200
- CountrySingapore
- Language:English
-
Abstract:
We report a case of systemic diffuse large B-cell lymphoma presenting with extensive infiltration of the skin. A 56-year-old woman presented with a two-month history of pruritic erythematous plaques and nodules over the neck, trunk and upper limbs. She also had night sweats, weight loss, lethargy and reduced effort tolerance. Systemic examination revealed a pale, ill appearance with hepatosplenomegaly and lymphadenopathy. Blood investigations showed pancytopenia (haemoglobin 6.3 g/dL, total white cell count 3.0 × 10(9)/L, platelet count 138 × 10(9)/L) with a few suspicious mononuclear cells and a mildly elevated lactate dehydrogenase level (478 U/L). Skin biopsy demonstrated diffuse sheets and nodular infiltrates of CD20 and CD79a positive neoplastic cells in the dermis and subcutis. Computed tomography revealed multiple cervical, axillary, mediastinal, para-aortic and mesenteric lymph nodes. Bone marrow aspiration and trephine biopsy confirmed marrow involvement by non-Hodgkin's lymphoma. The patient was treated with chemotherapy, which resulted in resolution of the skin lesions.
