The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet.
- Author:
Guihua HUANG
1
;
Rongmei WANG
;
Defeng WANG
;
Zhiwen ZHANG
;
Shuhai DENG
Author Information
1. Institute of Drug Preparations, School of Pharmacy, Shandong University, Ji'nan 250012, China.
- Publication Type:Journal Article
- MeSH:
Delayed-Action Preparations;
Drug Compounding;
Hypromellose Derivatives;
Methylcellulose;
analogs & derivatives;
chemistry;
Metoprolol;
administration & dosage;
analogs & derivatives;
pharmacokinetics;
Pharmaceutic Aids;
chemistry;
Pharmaceutical Preparations;
chemistry;
Tablets;
Viscosity
- From:
Journal of Biomedical Engineering
2006;23(3):587-591
- CountryChina
- Language:Chinese
-
Abstract:
The hydroxypropyl methylcellulose (HPMC) matrix tablet containing metoprolol succinate (MS) as a model drug was obtained by wet method compression tablet. The effects of the amount and viscosity of HPMC, the preparation method, compressing pressure, the amount of ethycellulose (EC), the pH of dissolution medium and the speed of basket rotation on the drug release from the matrix tablets were evaluated. The results showed that the release rate of metoprolol succinate from HPMC matrix tablets followed Higuchi equation. The release mechanism was in line with the synthetical effect of diffusion and corrosion. Drug release was influenced by the amount and viscosity of HPMC, the amount of EC in matrices, the preparation method and compressing pressure, etc. Drug release was not influenced by the pH of dissolution medium used, and not by the speed of basket rotation, either.
