The Effect of Isoflurane or Propofol on Hepatic Transaminase in Healthy Hepatitis B Carrier Patients.
10.4097/kjae.2000.39.5.662
- Author:
Sun Chong KIM
1
;
Duck Ku BAE
;
Chun Sook KIM
;
Soon Im KIM
Author Information
1. Department of Anesthesiology, College of Medicine, Soonchunghyang University, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Anesthetics, intravenous: propofol;
Anesthetics, volatile: isoflurane;
Infection: hepatic;
hepatitis B carrier;
Liver: function;
transaminase
- MeSH:
Alanine Transaminase;
Aspartate Aminotransferases;
Hepatitis B*;
Hepatitis*;
Humans;
Isoflurane*;
Orthopedics;
Plasma;
Propofol*
- From:Korean Journal of Anesthesiology
2000;39(5):662-666
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Isoflurane or propofol has been known to have a low potential for hepatotoxicity. The purpose of this study is to evaluate the effect of isoflurane or propofol on hepatic transaminase in healthy hepatitis B carrier patients. METHODS: Forty-six patients who were healthy hepatitis B carriers were studied following an orthopedic surgery. The patients were randomly assigned to Group I (n = 22) who received isoflurane, or group P (n = 24) who received propofol. The plasma concentrations of aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured on the day before the operation, and 1, 3, and 7 days after the operation. RESULTS: The plasma concentrations of AST were not changed significantly until the 7th day post-operatively in both groups, and there were no significant differences between the two groups. The plasma concentrations of ALT were significantly decreased at 1 and 3 days postoperatively (P < 0.05) in both groups. However, it recovered to baseline concentrations at 7 days postoperatively. There were no significant differences between the two groups. CONCLSIONS: The use of isoflurane or propofol does not increase the plasma concentrations of hepatic transaminase in Hepatitis B carrier patients after an operation.
